Wolverhampton's hospital has announced plans to shed 300 staff over the next five years.
The jobs, at New Cross Hospital in Wolverhampton, will be lost through natural wastage, but are likely to affect all areas, a spokesman said.
In the Spending Review, Chancellor George Osborne said he wanted to increase NHS spending; but obviously not here.
The hospital said it was looking to save around £9m this year.
In a statement the spokesman said: "We have no detailed plans in place as yet and if jobs do go we would pursue this through natural wastage first and of course, through redeployment.
"We anticipate a reduction of around 300 staff over a period of five years." source BBC website 3 November 2010